migraine Headaches

oral and topical treatments and commonly compounded formulations for migraine headaches


A unique vitamin and herbal formula synergistically designed to help reduce the frequency and intensity of cranial vascular disturbances

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This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.



Available with a doctor's prescription

  • Piroxicam 40mg sublingual troches

Within 2 hours of onset of migraine, put one troche under the tongue. Pain relief often observed within 15 minutes and headache may be gone in one hour.

Case Report
Ketoprofen/Riboflavin/Caffeine Capsules and Progesterone Therapy for Recurrent Migraine Pain. Int J Pharm Compd. 2007 May-June;11(3):200

  • ketoprofen 12.5mg/riboflavin 100 mg/caffeinecitrate 65mg capsules
  • Alternate formula: Riboflavin 200 mg/Caffeine 30 mg/Ketoprofen 12.5 mg capsules

A 40 year old woman with history of hysterectomy at age 28 and recurrent migraines refractory to treatment with multiple triptans and ergotamine/caffeine suppositories was prescribed a compounded therapy of ketoprofen 12.5mg/riboflavin 100 mg/caffeinecitrate 65mg capsules, with directions to take 2 capsules at onset of migraine then two capsules every 4 hours as needed. After 3 weeks, she reported that on four occasions, her migraine was relieved with only the onset dose, and on one other occasion, she required a follow-up dose.

She then added topical progesterone cream (applied twice daily) and three months later reported that she had only two migraines in the three month period, and both were relieved with the Ketoprofen/Riboflavin/Caffeine Capsules.


Available with a doctor's prescription

  • Ketoprofen 10%, gabapentin 6%, tetracaine 1%. in PLO gel or topical lipoderm cream

For headaches on the front quadrant of the head, apply 0.2 mL behind the ear where the jaw ends and/or the temple on the headache side of the head. If the headache is on the back of the head, then apply the gel/cream to the hair line on the neck on the side of the headache.

Any of the components below individually or combined may be used for acute migraine treatment. A physician may choose to start with one or two different agents and add, subtract or substitute based on patient response.

  • Tramadol HCl 5%
  • Doxepin HCl 5%
  • Ketamine 2.5-5%
  • Ketoprofen 15%
  • Lidocaine 2-5%
  • Diclofenac 4%
  • Indomethacin 1-10%
  • MgCl or MgSo4 5-10%
  • Caffeine, anhydrous 5%
  • Flurbiprofen 2.5-10%
  • Gabapentin 3.5-6%
  • Amitriptyline 1.5-3%
  • Sumatriptan 3-5%

Sample formulas for migraine treatment

Available with a doctor's prescription

  • Flurbiprofen 10%/Cyclobenzaprine HCl 1%/Gabapentin 6%/Lidocaine 2%/Prilocaine HCl 2% Topical Lipoderm
  • Ketamine5%/Sumitriptan5%/Flurbiprofen10%/Gabapentin 6%/Cyclobenzaprine2%/Topiramate2% Topical Lipoderm®
  • Sumatriptan 5%/Tramadol HCl 5%/Gabapentin 5%/Doxepin HCl 5%/Indomethacin 5% Topical Lipoderm®
  • Ketoprofen 15%/Lidocaine 5%/Magnesium Cl or Sulfate Cream 10%
  • Ketamine 5%/Gabapentin 6%/Amitriptyline 3%/Indomethacin 5%/Cyclobenzaprine 3%/Lidocaine 2% Topical Lipoderm®.
  • Indomethacin 10% and MgCl 10%
  • Ketoprofen 15%/Lidocaine 5%/Magnesium Cl or Sulfate Cream 10%
  • Ketoprofen 10%/Piroxicam 2.5%
  • Indomethacin 5%, mag chloride hexahydrate 5%
  • Mag chloride hexahydrate 10%, indomethacin 1%, caffeine anhydrous 5%
  • Sumatriptan 3.3%, ketamine 2.5%, flurbiprofen 2.5%, gabapentin 3.5%, amitriptyline 1.5%
  • Sumatriptan 5%, tramadol HCl 5%, gabapentin 5%, doxepin HCl 5%, indomethacin 5%
  • Rectal Suppository Treatment: Indomethacin 25mg, prochlorperazine dimaleate 4 mg, caffeine 75 mg